Drug-induced Gingival Overgrowth Related to Sirolimus and Felodipine
박연정, 이주희, 김영건, 권정승, 안형준, 최종훈,
소속 상세정보
박연정 ( Park Youn-Jung ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
이주희 ( Lee Joo-Hee ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
김영건 ( Kim Young-Gun ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
권정승 ( Kwon Jeong-Seung ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
안형준 ( Ahn Hyung-Joon ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
최종훈 ( Choi Jong-Hoon ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
KMID : 1101020170420010020
Abstract
Drug-induced gingival overgrowth (DIGO) is an adverse drug reaction mainly described withthree types of commonly prescribed drugs, namely, calcium channel blockers (CCBs) (nifedipine,diltiazem, and verapamil), anti-convulsants (phenytoin), and immunosuppressive agents (cyclosporine). Numerous reports have associated gingival overgrowth with the newer generationof immunosuppressive agents (tacrolimus, sirolimus, and everolimus), and CCBs (amlodipine,felodipine, nicardipine, and manidipine). Especially, patients concomitantly medicated with animmunosuppressive agent and CCB have a higher DIGO chance. Dentists need to be aware ofdrugs that induce gingival overgrowth, the possibility of DIGO, and risk factors, and also preventthe progression of DIGO by early detection of DIGO, consultation about the drug change,and the maintenance of strict dental hygiene regimes.
키워드
Calcium channel blockers; Gingival overgrowth; Immunosuppressive agents
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